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【產品簡介】
【詳細說明】
AD-1
Kv1.3 channel blocker(鉀離子通道Kv1.3阻斷劑)
AD-1 is an optimised synthetic analog of the scorpion peptide BmKTx. AD-1 is known to block voltage-gated mKv1.3 channel with a high affinity (IC50 = 1.89 pM) and selectivity (340 fold greater affinity than for voltage-dependent ).AD-1 inhibits CD4+ CCR7- T-cell proliferation. AD-1 is an interesting therapeutic candidate to treat auto-immune disorders such as multiple sclerosis, type-1 diabetes, rheumatoid arthritis and psoriasis. This peptide is a valuable tool for studying the structure-function of Kv1.3 channel and auto-immunity pathways.
AD-1 技術資料
氨基酸序列：
Val-Gly-Ile-Asn-Val-Lys-Cys7-Lys-His-Ser-Arg-Gln-Cys13-Leu-Lys-Pro-Cys17-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys27-Thr-Asn-Gly-Lys-Cys32-His-Cys34-Thr-Pro-Lys-OH
二硫鍵：Cys7-Cys27, Cys13-Cys32, Cys17-Cys34
長度 (aa)： 37
分子式：C169H281N57O46S7
分子量： 4071.90 Da
外觀： White lyophilized solid
可溶性： water and saline buffer
CAS 號：not available
來源： Synthetic
純度： > 98%
產品信息
13ADW001-00100 | AD-1 | 0.1mg |
13ADW001-00500 | AD-1 | 0.5mg |
13ADW001-01000 | AD-1 | 1mg |