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Febuxostat sodium

CAS No. : 1140907-13-6

產(chǎn)品活性：Febuxostat (TEI 6720) sodium is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a K_i value of 0.6 nM. Febuxostat sodium has the potential for the research of hyperuricemia and gout.

研究領(lǐng)域：Metabolic Enzyme/Protease

作用靶點(diǎn)：Xanthine Oxidase

In Vitro: Febuxostat sodium displays potent mixed-type inhibition of the activity of purified bovine milk xanthine oxidase, with K_i and K_i' values of 0.6 nM and 3.1 nM respectively, indicating inhibition of both the oxidized and reduced forms of xanthine oxidase.

In Vivo: Febuxostat sodium (5-6 mg/kg; i.e.; daily for 4 weeks) (fed a high-fructose diet (60% fructose) for 8 wk) significantly reduces lomerular pressure, renal vasoconstriction, and afferent arteriolar area relative to fructose+P rats, and shows no significant effects in rats on a normal diet when febuxostat treatment alone.
Febuxostat sodium (3-4 mg/kg; p.o.; daily for 4 weeks) with oxonic acid (750 mg/kg; oral gavage; daily for 4 weeks) preventes renal injury in 5/6 Nx (5/6 nephrectomy) rats with and without coexisting hyperuricemia.
Febuxostat sodium (2.5 mg/kg; p.o.; daily for 12 weeks) inhibits plaque formation in ApoE?/? mice and reduces the levels of ROS in the aortic wall of atherosclerotic mice.
Febuxostat sodium (15.6 mg/kg; p.o.; once daily for 21 successive days) shows antidepressant effect by significantly reduces the immobility time in the FST in mouse.
Febuxostat sodium (10 mg/kg; p.o.; daily for 21 days) administration with doxorubicin caused a significant decrease in nephrotoxicity markers and inflammatory mediators, restoration of normal values of oxidative stress biomarkers and hampering the expression of renal caspase-3.

相關(guān)產(chǎn)品：Xanthine oxidoreductase-IN-5  |  Xanthine oxidoreductase-IN-4  |  Lobetyolin  |  Xanthine oxidoreductase-IN-3  |  Xanthine oxidoreductase-IN-1  |  Myricetin 3-O-galactoside  |  Benzbromarone-d₅  |  Allopurinol  |  XO/COX/LOX-IN-1  |  Purpurogallin  |  Topiroxostat  |  Prudomestin  |  Xanthine oxidase-IN-1  |  Xanthine oxidase-IN-4  |  Xanthine oxidoreductase-IN-2  |  Oxypurinol  |  Xanthine oxidase-IN-6  |  Ellagic acid 4-O-β-D-xylopyranoside  |  Febuxostat-d₉  |  Febuxostat-d₇  |  Phytic acid dodecasodium hydrate  |  Benzbromarone  |  Flazin  |  Xanthine oxidase-IN-7  |  Fraxamoside  |  Xanthine oxidase-IN-9  |  Allopurinol-d₂  |  Nequinate  |  Tigulixostat

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