MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務。

GLPG0187

CAS No. : 1320346-97-1

產品活性：GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits α_vβ₁-integrin with an IC₅₀ of 1.3 nM. GLPG0187 inhibits migrasome biogenesis without cytotoxicity.

研究領域：Cytoskeleton

作用靶點：Integrin

In Vitro: In a solid-phase assay, GLPG0187 shows selectivity for several RGD integrin receptors with IC₅₀s of 1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM for α_vβ₁, α_vβ₃, α_vβ₅, α_vβ₆,α_vβ₈, and α₅β₁. GLPG0187 is a potent inhibitor of osteoclastic bone resorption and angiogenesis. Treatment with GLPG0187 dose-dependently increases the E-cadherin/vimentin ratio, rendering the cells a more epithelial, sessile phenotype. GLPG0187 dose-dependently diminishes the size of the aldehyde dehydrogenase high subpopulation of prostate cancer cells. GLPG0187 treatment results in cell rounding and clumping. GLPG0187 demonstrates a dose-dependent significant reduction in tumour cell migration. GLPG0187 at all concentrations significantly reduces cell proliferation.

In Vivo: Blocking α_v-integrins by GLPG0187 markedly reduces their metastatic tumor growth. Bone tumor burden is significantly lower and the number of bone metastases/mouse is significantly inhibited. The progression of bone metastases and the formation of new bone metastases during the treatment period is significantly inhibited.

相關產品：Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Cytoskeleton Compound Library  |  Targeted Diversity Library  |  Membrane Protein-targeted Compound Library  |  GRGDSPK  |  EILEVPST  |  Arg-Gly-Asp-Ser TFA  |  MK-0429  |  Tirofiban hydrochloride monohydrate  |  Anti-Mouse IL-1a Antibody  |  Echistatin  |  TC113  |  BIRT 377  |  αvβ1 integrin-IN-1  |  Enlimomab  |  Lys-Gln-Ala-Gly-Asp-Val  |  TC-I 15  |  Valategrast hydrochloride  |  Carotegrast  |  Irigenin  |  Integrin modulator 1  |  αvβ5 integrin-IN-1  |  RGD  |  Abituzumab  |  Zaurategrast  |  Surfactin C1  |  BOP sodium  |  Tirofiban-d₉  |  α2β1 Integrin Ligand Peptide TFA  |  Fradafiban  |  Firategrast  |  SB-273005  |  Fibronectin

熱門產品線：重組蛋白  |  化合物庫  |  天然產物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*僅有化合物庫，我們致力于為*科研客戶提供前沿的高品質小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領；
•   產品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產品，廣泛應用于新藥研發、生命科學等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學分析檢測分析，藥物篩選等專業技術服務；
•   設有專業的實驗中心和嚴格的質控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質檢報告，確保產品的高純度、高品質；
•   產品的生物活性多經各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業團隊跟蹤新的制藥及生命科學研究進展，為您提供*新的活性化合物；
•   與世界各大制藥公司及*科研機構建立了長期的合作。