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Lirentelimab

CAS No. : 2283348-97-8

產品活性：Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis.

研究領域：Apoptosis

作用靶點：Apoptosis

In Vitro: Monovalent Lirentelimab fragment antigen-binding (fab) binds to recombinant SIGLEC8 extracellular domain (ECD) is determined to be 464 pM.
Lirentelimab shows high affinity to SIGLEC8 in vitro, to SIGLEC8 expressed on eosinophils, and to NK cells via its Fc region in human blood.
Lirentelimab (1 µg/mL) selectively binds to eosinophils in human peripheral blood, and eosinophils and mast cells from human lung tissue.
Lirentelimab (0.0001-100 μg/mL; 30 min) induces apoptosis of IL-5-activated eosinophils.
Lirentelimab (30 min) shows potent antibody-dependent cell-mediated cytotoxicity (ADCC) Activity on human eosinophils with an EC₅₀ value of 1.9 ng/mL to eosinophils in peripheral blood leukocytes (PBL) preparations from healthy donors.
Lirentelimab reduces eosinophil numbers in ex vivo human tissue.

In Vivo: Lirentelimab (100 μg; i.v. once) significantly inhibits IgE-mediated mast cell activation in a mice model of systemic anaphylaxis.

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