目錄:MedChemExpress LLC>>生化試劑>> Luspatercept | MCE
CAS | 1373715-00-4 | 供貨周期 | 現貨 |
---|---|---|---|
貨號 | HY-P99720 | 應用領域 | 醫療衛生,化工,生物產業,制藥/生物制藥 |
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CAS No. : 1373715-00-4
產品活性:Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia.
研究領域:Stem Cell/Wnt | TGF-beta/Smad
作用靶點:TGF-beta/Smad
In Vitro: Luspatercept (0.1-1000 ng/mL) inhibits Smad2 and Smad 3 signaling induced by GDF11 and GDF8 in A204 cells.Luspatercept binds with GDF11, GDF8, activin B, BMP10 and BMP6.
In Vivo: Luspatercept (0.1-60 mg/kg, s.c.; 10 mg/kg, i.v.; twice weekly for 8 weeks) increases red blood cell (RBC) count, hemoglobin levels and hematocrit in mice, rats and monkeys.Luspatercept (10 mg/kg; s.c., once) reduces erythroid burst forming units (BFU-Es) and erythroid colony-forming units (CFU-Es) from bone marrow and spleen of C57BL/6 mice.Luspatercept (10 mg/kg; i.p., once) inhibits Smad2/3 phosphorylation in mouse spleen.
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